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Typical dosing for Ampicillin. sprite 500 ml Adults and children weighing over 20 kg (44 1 lbs): Respiratory tract infections: The typical dose is 250 mg by mouth 4 times a day (or every 6 hours) Gastrointestinal tract infections: The typical dose is 500 mg by mouth 4 times a day (or every 6 hours) Urinary and reproductive system infections: The typical